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North Thames Genomics Laboratory Hub – Band 5 Scientific Support Technologist

Job Reference: 271-MTT-4327596
Employer: Great Ormond Street Hospital for Children NHS Foundation Trust
Location: Great Ormond Street Hospital

Grade: Band 5
Hours: Full time – 37.5 hours per week

Contract: Fixed term 12 months
Salary: £30,786 – £37,841 per annum pro rata inclusive

Closing: 22/08/2022

Click here for more information and to apply

We are seeking proactive individuals to join the Rare and Inherited Disease Genomics Laboratory at Great Ormond Street Hospital. They will provide a highly professional, comprehensive and efficient scientific support service to our scientific teams.

The Rare Disease Laboratory has an establishment of approximately 140 including technologists, clinical scientists, translational scientists, bioinformaticians and administrative support staff. Along with two Clinical Genetics teams we form a strategic Genetics Unit within the hospital and provide North London with a Regional Genetics Service serving a population of approximately 10 million.  The genetics laboratory provides an in-house diagnostic service for cancer, molecular genetic and cytogenetic testing in accordance with the NHS England Genomic Test Directory. Cytogenetic testing is provided for both prenatal and postnatal samples using SNP microarray, karyotyping, FISH, qPCR, QFPCR and MLPA. Molecular testing includes next generation sequencing and targeted tests. We are also engaged in the development and ramping up of the NHSE Genomic Medicine Service Whole Genome Sequencing programme for our North Thames patients.

We are involved in a number of collaborative research and development projects with colleagues at the UCL Institute of Child Health and Institute of Neurology as part of the UCL Partners Academic Health Sciences Centre. We provide a DNA preparation and storage service in support of many of these projects.

Main duties of the job

You will be responsible for ensuring that samples are assigned to the correct testing pathway through the laboratory.

Depending on current skills and experience, you will also undertake analytical work as required in the support of a genomic testing service for one of our scientific teams (e.g. Molecular targeted;  Karyotype).

You will contribute to the smooth running of the North Thames Rare Disease Laboratory and must be able to demonstrate a high level of skill in molecular and/or cytogenetic techniques. Genetic knowledge and hands on experience in an accredited diagnostic setting will be an advantage. Good communication skills and attention to detail are essential.

For further details or informal visits contact:

Deborah Morrogh, Head of Service

Deborah.Morrogh@gosh.nhs.uk

North Thames Genomics Laboratory Hub – Band 4 Assistant Genetic Technologist

Job Reference: 271-MTT-4419210
Employer: Great Ormond Street Hospital for Children NHS Foundation Trust
Location: Great Ormond Street Hospital

Grade: Band 4
Hours: Full time – 37.5 hours per week

Contract: Permanent
Salary: £27,157 – £29,859 per annum inclusive

Closing: 22/08/2022

Click here for more information and to apply

We are seeking an assistant genetic technologist who has experience of genomic techniques to join the North Thames Rare Disease Laboratory Hub at Great Ormond Street Hospital.

A vacancy has arisen in our Cytogenetic team although rotation between teams (Preparation; Molecular targeted; WGS; NGS; Robotic) may be arranged.

Main duties of the job

You will contribute to the smooth running of the North Thames Rare Disease Genomic Laboratory and should have some demonstrable experience of DNA preparation, molecular and/or cytogenetic techniques; hands on experience in an accredited diagnostic setting will be an advantage. Good communication skills and attention to detail are essential.

The Rare Disease Laboratory has an establishment of approximately 140 including technologists, clinical scientists, translational scientists, bioinformaticians and administrative support staff. Along with two Clinical Genetics teams we form a strategic Genetics Unit within the hospital and provide North London with a Regional Genetics Service serving a population of approximately 10 million. The genetics laboratory provides an in-house diagnostic service for cancer, molecular and cytogenetic testing in accordance with the NHS England Genomic Test Directory. Cytogenetic testing is provided for both prenatal and postnatal samples using SNP microarray, karyotyping, FISH, qPCR, QF PCR and MLPA. Molecular testing includes next generation sequencing approaches and targeted tests. We are also engaged in the NHSE Genomic Medicine Service Whole Genome Sequencing programme for our North Thames patients.

We are involved in a number of collaborative research and development projects with colleagues at the UCL Institute of Child Health and Institute of Neurology as part of the UCL Partners Academic Health Sciences Centre.

For further details or informal visits contact:

Claire Jones, Lead Genetic Technologist

Claire.Jones@gosh.nhs.uk

Medical Technical Officer at the The Royal Marsden Hospital Sutton

Job Reference: 282-SA123523
Employer: The Royal Marsden NHS Foundation Trust
Location: The Royal Marsden Hospital Sutton
Grade: Band 5
Hours: Full time – 37.5 hours per week

Contract: Permanent
Salary: £29,553 to £36,265 a year per annum
Closing: 16/08/2022

Click here for more information and to apply

An exciting opportunity has arisen for a Medical Technical Officer with good interpersonal skills and a committed team member to join the Molecular Diagnostics team within the Clinical Genomics department. The department is located in the Centre for Molecular Pathology and is one of seven national Genomic Laboratory Hubs offering Cancer Genomic testing in England. The department provides a reference Molecular Diagnostics and Cytogenetics Service for solid tumours and haematological malignancies, as well as participating in clinical trials.

The post holder will be responsible for carrying out analytical molecular diagnostics including, but not limited to, Next Generation Sequencing, fragment analysis, ddPCR and gene expression analysis. The post holder will be expected to assist in training of junior members of the team and support activities such as quality, equipment maintenance and audits

The successful applicant must have a relevant BSc degree in Biological Sciences/Genetics and have experience in molecular diagnostics techniques. Please note: total weekly working hours are 37.5 hours, however in line with the NHSE requirements for the delivery of the Cancer Test Directory, the Clinical Genomics department will operate an extended working hours service, the post holder will be required to participate in a shift system on a rotational basis.

Main duties of the job

The post holder will undertake technical duties required to support scientific teams in the provision of an effective and high quality molecular diagnostics service to patients. They will be responsible for carrying out analytical molecular diagnostics investigations, with minimal supervision. The range of tests available will be in continuous development and the post-holder will be expected to work within all areas of the department. Analytical investigations will include, but not limited to, Next Generation Sequencing, fragment analysis, ddPCR and gene expression analysis in haematological and solid tumours. The key working relationships will be with clinicians, oncologists and histopathologists responsible for treating patients as well as with other Pathology disciplines and liaising with staff throughout the Trust. The post holder will be expected to assist in training of junior members of the team and visitors as well as to contribute to data management relating to the technical aspects of the molecular service. In addition the post holder will be required to support activities such as quality, including compliance with laboratory accreditation standards, equipment maintenance, audits and participate in the departments training programme.

For further information on this role please contact Emma Poyastro-Pearson, emma.pearson@icr.ac.uk

Band 7 Registered Clinical Scientist /Pre Registrationat Imperial College Healthcare NHS Trust

Job Reference: 290-DP-520
Employer: Imperial College Healthcare NHS Trust
Location: North West London Pathology at Hammersmith Hospital
Grade: Band 7
Hours: 12 months fixed term contract

Contract: Permanent
Salary; £39,702 to £47,154 a year
Closing: 22/08/2022

Click here for more information and to apply

Applications are invited from State Registered Clinical Scientists / Pre-Registration Clinical Scientists in Genetics to join the SIHMDS Laboratory within North West London Pathology at Hammersmith Hospital and part of the North Thames Genomic Laboratory Hub (NTGLH).

We are seeking an enthusiastic, self-motivated Clinical Scientist with extensive experience of Cancer Cytogenetics to work primarily in the cytogenetics section of our laboratory and contribute to the provision of a timely and efficient ISO15189 accredited service.

International or UK applicants without HCPC registration but with extensive experience of bone marrow karyotyping and FISH analysis will also be considered at Band 7 Annex U level until HCPC registration is completed. At either level, experience with analysis and reporting of next generation sequencing and whole genome sequencing is also desirable as an integrated working within both cytogenetics and molecular is expected.

The post holder will be required to take responsibility for delivering a high-quality routine laboratory diagnostic service for a range of specialised cytogenetic and molecular investigations including analysis, result evaluation, interpretation, and reporting of haematological malignancies in a clinical setting. This post holder will have duty scientist responsibilities in the wet laboratory and have overall management of the technical staff. Therefore good communication, team working and supervisory skills are essential.

Main duties of the job

1. Deliver a range of complex scientific/informatics work demanding skilled performance that may be with or without scientific or technical support.

2. Deliver with the Consultant Clinical Scientist, Pathologist and Divisional Manager a routine service to nationally accepted standards

3. Achieve competence in the interpretation of test results and the provision of clinical advice, under supervision. They are not supervised but may refer complex cases to a superior.

4. Participate in audit, research and development in the agreed specialist area.

5. Participate in local and national professional training and be expected to obtain Part 1 FRCPath (Associate) – or equivalent – while in post.

For further details / informal visits contact:

Dr Udayakumar Achandira udayakumar.achandira@nhs.net