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Great Ormond Street Hospital – Band 8a Senior Project Manager

Job Reference: 271-MTT-3817929-A
Employer: Great Ormond Street Hospital for Children NHS Foundation Trust
Location: Great Ormond Street Hospital

Grade: Band 8a
Hours: Full time – 37.5 hours per week

Contract: Fixed Term – 12 months
Salary: £54,223 to £60,316 a year per annum pro rata inclusive

Closing: 30/05/2022

Click here for more information and to apply

This is an opportunity for an experienced Senior Informatics Project Manager. Applications are invited for an experienced Senor Informatics Project Manager with experience of working in the NHS and the use of clinical systems. Prince and MSP qualification would be an advantage.

The successful candidate will take on a senior informatics project manager role at the North Thames Genomics Laboratory Hub at Great Ormond Street Hospital. The North Thames GLH will provide all core Rare Disease and Cancer testing for this area as well as some specialist Rare Disease testing at a sub-national level.. The North Thames GLH is a partnership between several Trusts across North London. Led by Great Ormond Street NHS Foundation Trust the partners include Barts Health, Imperial College Hospital and its partner laboratory Northwest London Pathology, the Royal Marsden Hospital, UCLH NHS Foundation Trust and the Royal Free Hospital with their partner laboratory Health Services Laboratory, and the Royal National Orthopaedic Hospital.

Main duties of the job

We are seeking enthusiastic, self-motivated experienced individual with significant experience of programme delivery and a sound understanding of the impact to clinical and scientific teams regarding the projects they are delivering. Accomplished communication and organisational skills are required; management experience is an advantage.

Within the NTGLH, the GOSH and RMH laboratories will be utilising EPIC Beaker. Opportunities for automation and integration of laboratory data to the LIMS will be implemented to achieve operational efficiencies and the removal of manual data entry. The key objective is to implement order comms and reporting for GLH users. This may include joint working with other GLH EPIC users (e.g., Cambridge and GSTT) and the NT GMSA.

For further details or informal visits contact:

Susan McGregor, susan.mcgregor@gosh.nhs.uk

Great Ormond Street Hospital – Band 5 Genetics Technologist

Job Reference: 271-MTT-4088793
Employer: Great Ormond Street Hospital for Children NHS Foundation Trust
Location: Great Ormond Street Hospital

Grade: Band 5
Hours: Full time – 37.5 hours per week

Contract: Fixed Term – 12 months
Salary: £30,786 – £37,841 per annum pro rata inclusive

Closing: 27/05/2022

Click here for more information and to apply

We are seeking experienced genetic technologists who can demonstrate skilled use of genomic techniques to join the North Thames Rare Disease Laboratory Hub at Great Ormond Street Hospital.

Depending on current skills and experience, the postholders will be assigned to one of our process based teams (Preparation; NGS/NIPD; Molecular targeted; Cytogenetic) although rotation between teams may be arranged.

You will contribute to the smooth running of the North Thames Rare Disease Laboratory and must be able to demonstrate a high level of skill in molecular and/or cytogenetic techniques; hands on experience in an accredited diagnostic setting will be an advantage. Good communication skills and attention to detail are essential.

Main duties of the job

The Rare Disease Laboratory has an establishment of approximately 140 including technologists, clinical scientists, translational scientists, bioinformaticians and administrative support staff. Along with two Clinical Genetics teams we form a strategic Genetics Unit within the hospital and provide North London with a Regional Genetics Service serving a population of approximately 10 million. The genetics laboratory provides an in-house diagnostic service for cancer, molecular genetic and cytogenetic testing in accordance with the NHS England Genomic Test Directory. Cytogenetic testing is provided for both prenatal and postnatal samples using SNP microarray, karyotyping, FISH, qPCR, QFPCR and MLPA. Molecular testing includes next generation sequencing and targeted tests. We are also engaged in the development and ramping up of the NHSE Genomic Medicine Service Whole Genome Sequencing programme for our North Thames patients.

We are involved in a number of collaborative research and development projects with colleagues at the UCL Institute of Child Health and Institute of Neurology as part of the UCL Partners Academic Health Sciences Centre. We provide a DNA preparation and storage service in support of many of these projects.

For further details or informal visits contact:

Louise Lewis, Senior Genetic Technologist: Louise.Lewis@gosh.nhs.uk

Great Ormond Street Hospital – Band 4 Administration Coordinator

Job Reference: 271-MTT-4110812-A
Employer: Great Ormond Street Hospital for Children NHS Foundation Trust
Location: Great Ormond Street Hospital

Grade: Band 4
Hours: Full time – 37.5 hours per week

Contract: Permanent
Salary: £27,157 – £29,859 per annum inclusive

Closing: 10/06/2022

Click here for more information and to apply

We are seeking an enthusiastic, motivated and hardworking Administration Coordinator to join our team at the London North Genomic Laboratory Hub (GLH) at Great Ormond Street Hospital NHS Trust. Candidates should hold A-levels or an equivalent qualification.

The Administration Coordinator will actively manage the administrative processes required for the smooth and efficient operation of the laboratories’ activities. They will supervise Administration Assistants and work closely with the Administration Manager and other members of the administrative team, in order to deliver a high quality administration service, a positive patient experience, and excellent customer service.

The Genetics Laboratory has an establishment of approximately 120 staff including clinical scientists, translational scientists, bioinformaticians, technologists and administrative support staff. .

The genetics laboratory provides an in-house diagnostic service for molecular and cytogenetic testing. Cytogenetic testing is provided for both prenatal and postnatal samples using SNP microarray, karyotyping, FISH, qPCR, and QF PCR. Molecular testing includes a number of common single gene disorders with an extensive next generation sequencing repertoire; we also provide national and international services for non-invasive prenatal diagnosis, deafness, craniofacial, metabolic and immune deficiency disorders.

Main duties of the job

The Rare Disease Laboratory has an establishment of approximately 140 including technologists, clinical scientists, translational scientists, We are involved in a number of collaborative research and development projects with colleagues at the UCL Institute of Child Health and Institute of Neurology as part of the UCL Partners Academic Health Sciences Centre. We also provide a DNA preparation and storage service in support of many of these projects.

For further details or informal visits contact:

Far-Ming Fung, Administration Manager: genlabs.adminmgmt@gosh.nhs.uk

Medical Technical Officer at the The Royal Marsden Hospital Sutton

Job Reference: 282-SA122896-A
Employer: The Royal Marsden NHS Foundation Trust
Location: The Royal Marsden Hospital Sutton
Grade: Band 5
Hours: Full time – 37.5 hours per week

Contract: Permanent
Salary: £29,553 to £36,265 a year per annum inc HCAS
Closing: 23/05/2022

Click here for more information and to apply

An exciting opportunity has arisen for a Medical Technical Officer with good interpersonal skills and a committed team member to join the Molecular Diagnostics team within the Clinical Genomics department. The department is located in the Centre for Molecular Pathology and is one of seven national Genomic Laboratory Hubs offering Cancer Genomic testing in England. The Centre for Molecular Pathology is a state-of-the-art facility bringing together translational science and molecular diagnostics and is one of the few specialised laboratories in molecular diagnostics of cancer in Europe.

We are seeking an enthusiastic Medical Technical Officer to contribute to the provision of a timely and efficient ISO 15189 accredited Clinical Genomics Service. The post holder will undertake technical duties required to support scientific teams in the provision of an effective and high quality service to patients. The post holder must be able to take responsibility for working alone and as part of a team to achieve necessary performance levels. They will be responsible for carrying out analytical molecular diagnostics investigations, with minimal supervision. Analytical investigations will include, but not limited to, Next Generation Sequencing, fragment analysis, ddPCR and gene expression analysis in haematological and solid tumours.

Main duties of the job

The post holder will undertake technical duties required to support scientific teams in the provision of an effective and high quality molecular diagnostics service to patients. They will be responsible for carrying out analytical molecular diagnostics investigations, with minimal supervision. The range of tests available will be in continuous development and the post-holder will be expected to work within all areas of the department. Analytical investigations will include, but not limited to, Next Generation Sequencing, fragment analysis, ddPCR and gene expression analysis in haematological and solid tumours. The key working relationships will be with clinicians, oncologists and histopathologists responsible for treating patients as well as with other Pathology disciplines and liaising with staff throughout the Trust. The post holder will be expected to assist in training of junior members of the team and visitors as well as to contribute to data management relating to the technical aspects of the molecular service. In addition the post holder will be required to support activities such as quality, including compliance with laboratory accreditation standards, equipment maintenance, audits and participate in the departments training programme.

For further information on this role please contact Emma Poyastro-Pearson, emma.pearson@icr.ac.uk

Royal National Orthopaedic Hospital NHS Trust – Clinical Fellow

Job Reference: 392-MS232-HISCF
Employer: Royal National Orthopaedic Hospital NHS Trust
Location: Royal National Orthopaedic Hospital
Hours: Full time – 37.5 hours per week

Contract: Fixed Term – 12 months
Salary: £33,790 to £53,132 a year + £2,162 LW per annum

Closing: 29/05/2022

Click here for more information and to apply

With the ever-increasing demands on trainees to deliver the service and obtain their CCST rapidly, there is often little time for learning new skills, and developing and introducing new ideas which could improve the quality and efficiency of the discipline.

This post has been developed to provide an individual who wishes to excel in the field of pathology the opportunity to develop skills to do just that. This will be achieved by ring-fencing 50% of the post for research and development in highly clinically-related areas, specifically genomics and /or computational/ digital pathology. These elements of the job will be acquired by working with clinician and computational scientists in UCL while acting as a link with the RNOH diagnostic team. The Fellow will be trained in skills which are transferable and have the potential to be usefully employed in all areas of diagnostic pathology. The Fellow will have dedicated time to work with clinician scientists at UCL. The skills acquired will allow the individual to continue to develop over their career and to respond to changes that are likely to take place over the coming decades because of the greater use of technology. If the Fellow were interested, they could enrol in a post-graduate degree, but this is not a requirement.

Main duties of the job

The Fellow will acquire high level diagnostic skills by supporting the 5 consultants in delivery of the clinical service. The experience and training will provide the successful candidate the opportunity to become a highly competent specialist consultant histopathologist over the 24months of the fellowship. Ideally, we would like to see the Fellow obtain a sarcoma post for which there is an unmet need across the UK and abroad however the skills acquired in this post would make then competitive for other areas in pathology if that is what they wished to pursue.

For further details or informal visits contact:

Simon Burn; simonburn1@nhs.net, 02089095354

The Neurogenetics Laboratory of the UCLH National Hospital for Neurology and Neurosurgery (NHNN) – Band 7 Clinical Bioinformatician

Job Reference: 309-SHB5561-MU-A
Employer: University College London Hospitals NHS Foundation Trust
Location: The Neurogenetics Laboratory of the UCLH National Hospital for Neurology and Neurosurgery (NHNN)

Grade: Band 7
Hours: Full time – 37.5 hours per week

Contract: Fixed Term – 12 months
Salary: £47,154 to £52,936 a year per annum inclusive pro rata

Closing: 25/05/2022

Click here for more information and to apply

The Neurogenetics Laboratory of the UCLH National Hospital for Neurology and Neurosurgery (NHNN) provides a regional, national and international diagnostic service for inherited neurological disease, including the Highly Specialised Services for Mitochondrial Disease and Rare Neuromuscular Disorders (skeletal muscle channelopathies). The Neurogenetics Laboratory is located alongside the Regional Genetics Laboratory at Great Ormond Street Hospital, forming the lead Rare Disease Laboratory in the North Thames Genomics Laboratory Hub (GLH).

The laboratory is ISO 15189:2012 accredited and has close associations with clinicians and research groups at the UCL Queen Square Institute of Neurology.

Main duties of the job

A full time HCPC-Registered Clinical Bioinformatician is required to participate in the provision of the molecular genetic service, this is a 1-year fixed-term post covering for maternity leave. Applications will also be considered from candidates working towards registration. The post holder will work closely with the bioinformatics team at GOSH and within the North Thames GLH to maintain and develop in house pipelines for both nuclear and mitochondrial DNA NGS analysis as well as bespoke programs designed to facilitate analysis of whole genome sequence data. The role includes management of data storage and archiving. With the introduction of whole genome sequencing into the NHS diagnostic setting this is an evolving and challenging role suited to a flexible hardworking bioinformatician.

Previous experience in a diagnostic genetics laboratory or in NGS data analysis pipeline development and maintenance is essential; no previous experience in neurology is necessary.

For further details or informal visits contact:

Dr James Polke: james.polke@nhs.net

University College London Hospitals NHS Foundation Trust – Band 8b Senior Database Systems Manager

Job Reference: 309-CB5256-GT
Employer: University College London Hospitals NHS Foundation Trust
Location: Maple House Offices
, London, W1T 7NF
Grade: Band 8b
Hours: Full time – 37.5 hours per week

Contract: Fixed Term – 16 months
Salary: £61,861 to £70,959 a year per annum inclusive pro rata

Closing: 26/05/2022

Click here for more information and to apply

We welcome applicants for a Senior Database Systems Manager (Band 8b) to support the exciting, innovative cross NIHR BRC work based at UCLH known as the Haematology Data Science Initiative (HDSCI).

The NIHR Biomedical Research Centres (BRCs) at University College London Hospitals NHS Foundation Trust (UCLH) and Cambridge University Hospitals NHS Foundation Trust (CUH), together with NHS Blood and Transplant (NHSBT) have embarked on a new and exciting initiative to bring artificial intelligence and machine learning (AI&ML) solutions and genomics-informed clinical decision making to the frontline of NHS patient care.

The HDSCI project will be embedded in the BRC Clinical and Research Informatics Unit (CRIU) and the post-holder will be a member of the multidisciplinary HDSCI team, which includes clinical bioinformaticians, experts in statistical genomics, blood cell immunogenicity and randomised controlled trials, clinical haematologists caring for patients with inherited anaemias, and researchers in AI&ML.

The HDSCI centres on two main themes:

Haem-Match: Genomically informed AI driven precision blood matching to reduce the harm caused to patient through blood transfusion

Bloodcounts!: Using the data provided by the FBC, not visible to clinicians, to identify signatures of important medical conditions and to develop polygenic risk scores.

Main duties of the job

The post holder will be responsible, in close partnership with the CRIU Senior Management for identifying, supporting, and maintaining the computational platforms required for the delivery of the HDSCI project. Specifically, this will involve:

– Working with HDSCI team to understand the project needs

– Designing data models for clinical and research datasets with appropriate documentation and metadata

– Developing and installing database schemas to a variety of database platforms

– Establish project-required links to Genomics England Ltd, the NIHR BioResource and NHSBT, amongst others

– Working with staff at other NHS hospitals to retrieve project-relevant information

– Deploy federated models for the application of AI&ML at other NHS hospitals and non-UK hospitals

Develop appropriate Reporting and Data Delivery solutions to support the HDSCI project within the CRIU framework and TREs. This will include:

– Lead on the quality control, homogenisation, and analysis of clinical and laboratory data, including genomics data from several sources

– Work in close partnership with other members of the HDSCI team to develop data analysis plans, to execute these analyses and presented results at regular project meetings

– Using appropriate data-delivery mechanisms to satisfy the Information Governance and Security requirements applicable to the particular data request

– Ensuring all data processed for the project are handled in accordance with the applicable Data Governance arrangements

For further details or informal visits contact:

Louise English; louise.english2@nhs.net